Chronic hepatitis B (CHB) remains a major global healthcare challenge with changing epidemiology and increasing morbidity and mortality from the complications of liver cirrhosis and hepatocellular carcinoma (HCC). Hepatitis B virus infection can be broadly categorized into four disease phases: (1) hepatitis B e antigen (HBeAg)-positive chronic infection; (2) HBeAg-positive chronic hepatitis; (3) HBeAg-negative chronic …
by tirayrgurjanyan@gmail.com 
Introduction: Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is the third most common cardiovascular disease and, globally, more than an estimated 10 million people have it yearly. It is a chronic and recurrent disease. The symptoms of VTE are non‐specific and the diagnosis should actively be sought once considered. The mainstay …
by tirayrgurjanyan@gmail.com 
Objective: To estimate the prevalence of polypharmacy among Australians aged 70 years or more, 2006–2017. Design, setting and participants: Analysis of a random 10% sample of Pharmaceutical Benefits Scheme (PBS) data for people aged 70 or more who were dispensed PBS‐listed medicines between 1 January 2006 and 31 December 2017. Main outcome measures: Prevalence of continuous polypharmacy (five …
by tirayrgurjanyan@gmail.com
Objective: To estimate the prevalence of polypharmacy among Australians aged 70 years or more, 2006–2017. Design, setting and participants: Analysis of a random 10% sample of Pharmaceutical Benefits Scheme (PBS) data for people aged 70 or more who were dispensed PBS‐listed medicines between 1 January 2006 and 31 December 2017. Main outcome measures: Prevalence of continuous polypharmacy (five …
by tirayrgurjanyan@gmail.com 
Objectives: To assess the numbers of paracetamol overdose‐related hospital admissions and deaths in Australia since 2007–08, and the overdose size of intentional paracetamol overdoses since 2004. Design, setting: Retrospective analysis of data on paracetamol‐related exposures, hospital admissions, and deaths from the Australian Institute of Health and Welfare National Hospital Morbidity Database (NHMD; 2007–08 to 2016–17), the New …
by tirayrgurjanyan@gmail.com 
Objectives: To assess the clinical effectiveness of faecal calprotectin (FC) testing for distinguishing between organic gastrointestinal diseases (organic GID), such as inflammatory bowel disease (IBD), and functional gastrointestinal disorders (functional GIDs). Study design: Studies that assessed the accuracy of FC testing for differentiating between IBD or organic GID and functional GIDs were reviewed. Articles published in English …
by tirayrgurjanyan@gmail.com 
People with leprosy, a chronic granulomatous disease caused by Mycobacterium leprae, classically present with hypopigmented or erythematous, anaesthetic skin lesionsю or thickened peripheral nerves.
by tirayrgurjanyan@gmail.com 
Cereal yellow dwarf virus (CYDV) RNA has a 5′-terminal genome-linked protein (VPg). We have expressed the VPg region of the CYDV genome in bacteria and used the purified protein (bVPg) to raise an antiserum which was able to detect free VPg in extracts of CYDV-infected oat plants. A template-dependent RNA-dependent RNA polymerase (RdRp) has been produced …
by tirayrgurjanyan@gmail.com
Cereal yellow dwarf virus (CYDV) RNA has a 5′-terminal genome-linked protein (VPg). We have expressed the VPg region of the CYDV genome in bacteria and used the purified protein (bVPg) to raise an antiserum which was able to detect free VPg in extracts of CYDV-infected oat plants. A template-dependent RNA-dependent RNA polymerase (RdRp) has been produced …
by tirayrgurjanyan@gmail.com 
As many as 4 out of every 10 people will get sciatica, or irritation of the sciatic nerve, at some point in their life. This nerve comes from either side of the lower spine and travels through the pelvis and buttocks. Then the nerve passes along the back of each upper leg before it divides …
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